Projects
Our portfolio of Clinical trials and population studies
Obstetrics
| ESTEEM–To compare, in pregnant women with metabolic risk factors, the effect of simple, targeted diet (Mediterranean, including olive oil and nuts, composed within a culturally appropriate meal plan) vs. usual antenatal dietary advice in reducing the risk of pre-eclampsia. | SALVO – A randomised controlled trial of intra-operative cell salvage during caesarean section in women at risk of haemorrhage | PREP – Development and validation of a prediction model for risk of complications in early onset pre-eclampsia |
| EMPIRE – Antiepileptic drug (AED) management in Pregnancy: An evaluation of effectiveness, cost effectiveness and acceptability of dose adjustment strategies | PROP – How accurate is spot urinary protein: creatinine ratio (SPCr) and spot albumin-to-creatinine ratio (SACr) compared to 24-hour protein estimation to assess women with hypertensive disease in pregnancy (HDP) after 24 weeks gestation | GIFTS – Genomic and lifestyle predictors of foetal outcome relevant to diabetes and obesity and their relevance to prevention strategies in South Asian peoples (in collaboration with Centre for Diabetes, Blizard Institute, QMUL) |
| PrePro – Preventing Preterm Birth with Probiotics: A pilot double blind randomised controlled trial | GBS2 – Accuracy of a rapid intrapartum test for maternal Group B Streptococcal (GBS) colonisation and its potential to reduce antibiotic usage in mother with risk factors |
Gynaecology
| MEDAL – Can magnetic resonance imaging (MRI) scan replace or triage the use of laparoscopy in establishing a diagnosis among women presenting in secondary care with chronic pelvic pain (CPP). Project in collaboration with the University of Birmingham | BUS – Accuracy of Bladder Ultrasound (BUS) in the diagnosis of Detrusor Overactivity: a study to evaluate if ultrasound can reduce the need for urodynamics. Project in collaboration with the University of Birmingham |
Portfolio Studies supported by Katherine Twining Network
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| RAPID– Reliable Accurate Prenatal non-Invasive Diagnosis (RAPID) an integrated project to refine and implement safer antenatal testing for single gene disorders. | HABSELECT–To determine the efficacy of hyaluronan-selected Intracytoplasmic Sperm Injection (PICSI) versus PVP ICSI | DAPPA-To evaluate the accuracy of spot proteinuria in comparison to twenty four hour proteinuria in women with suspected pre-eclampsia |
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| STRIDER–To determine whether oral sildenafil improves outcomes in pregnancies complicated by severe early-onset intrauterine growth restriction without increasing risks to the mother. | PRISM–Effectiveness of progesterone to prevent miscarriage in women with early pregnancy bleeding: A randomised placebo-controlled trial | C-STICH–To examine the effect of using a monofilament suture material compared with a braided suture material on pregnancy loss rate (defined as miscarriage, stillbirth, neonatal death in the first week of life) and neonatal mortality up to one month post-delivery in women deemed to be at risk of an insufficient cervix and treated with cervical cerclage |
| HEALTH-to compare multicentre randomised controlled trial laparoscopic supracervical hysterectomy with second generation endometrial ablation for the treatment of heavy menstrual bleeding (HEALTH) |
Systematic Reviews and Health Technology Assessments
| Obesity in Pregnancy – Interventions to reduce or prevent obesity in pregnant women: A systematic review of evidence synthesis | Cervical Cancer (PET CT) – Clinical effectiveness of PET-CT imaging in restaging recurrent cervical cancer: Systematic review of evidence and economic modeling | Vulval Cancer (Sentinel Node) – Sentinel lymph node (SLN) status in vulval cancer: Systematic quantitative reviews and decision analytic model based economic evaluation |
| Therapeutic writing– Does therapeutic writing help people with long term conditions? Systematic review, realist synthesis and economic modelling | iWIP IPD M-A – Effects of weight management interventions on maternal and fetal outcomes in pregnancy: Individual patient data (IPD) meta-analysis of randomised trials and model based economic evaluation |
Medical education
| EBM Connect – Evidence-based Medicine Collaboration Network for guideline development, teaching and dissemination |
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